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Trump is using the latest COVID-19 treatment

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When President Trump, 74, and First Lady Melania Trump, 50, tested positive for coronavirus. What treatment has been proven best for them and other patients?

We are physician-scientists at the University of Virginia. We care for patients with COVID-19 and research for better ways to diagnose and treat COVID-19.

We are sharing what doctors have learned over the past eight months in treating the different stages of this disease. Few treatments are available for people who show severe symptoms of COVID-19. In addition to treatment using a ventilator months later Few treatments, including medications, provide doctors with much better tools to treat their patients. especially severely ill

Who is at risk of getting COVID-19? The most intense?

Men are one and a half times more likely to die than men, and people in their 80s are 20 times more likely to die than people in their 50s. In addition to age and gender, obesity; diabetes; Recent cancer diagnosis chronic heart, lung, and liver disease; strokes; and dementia were all associated with an increased risk of death from COVID-19. Presidents are classified as high-risk by gender and age of men.

Will treatment vary depending on the medical condition?

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Treatment methods vary depending on the stage of the disease.

It is therefore important not only to diagnose COVID-19, but to determine whether the infection is asymptomatic or pre-symptomatic. In addition, a person’s illness – whether mild, moderate, severe, or critical – Changing the way we treat patients

What are the treatments for asymptomatic or presymptomatic infections?

Asymptomatic or pre-symptomatic infection is defined as having a positive diagnostic test for COVID-19 (PCR test or antigen detection) without asymptomatic infection.

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There is currently no effective treatment for this procedure. Asymptomatic or pre-symptomatic infected people should self-quarantine at home for 10 days to prevent exposure to others.

What are the mild symptoms of the disease and what treatments are effective?

Mild symptoms of COVID-19 infection include fever, cough, loss of taste or smell. Muscle pain, headache, nausea, vomiting, diarrhea, nasal congestion and runny nose.

People with mild COVID-19 don’t experience shortness of breath, chest pain, or pneumonia during a chest X-ray. The exceptions are children with mild disease who may still have abnormal X-rays.

No treatment has been proven to benefit people with mild disease. However, such patients should be well informed about the symptoms of moderate illness. so that they and others Know if they have a moderate illness. This is important because progression of more severe disease can occur rapidly. It typically takes 5-10 days after the onset of symptoms.

moderate illness

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Moderate illness is defined as shortness of breath, chest pain, or chest X-ray. Evidence of pneumonia but no hypoxia (low blood oxygen levels)

There is currently no effective treatment for moderate illness.

serious disease

Severe illness can be identified by a rapid breathing rate (greater than 30 breaths per minute) or low blood oxygen levels. This is called hypoxia. In addition, evidence of pneumonia affecting more than half of the lungs. which was diagnosed by chest x-ray It’s a sign of a serious case.

Controlled clinical trials have shown that remdesivir accelerates recovery in patients with severe but non-fatal illnesses.

In addition, the anti-inflammatory steroid drug dexamethasone Prednisone (a drug similar to prednisone) also reduced death rates.

serious disease

Critical illness occurs when a patient becomes so ill that vital organs begin to fail. And they need medication or other treatment. to support these important functions.

If lung failure is severe enough The doctor may have the patient use a ventilator or give a high dose of oxygen. There is no evidence that treatment with remdesivir is helpful during this crisis. Dexamethasone is still recommended for treatment. because it was found to reduce the death rate

Which therapies are not working or are being tested?

Some treatments that don’t work include chloroquine and hydroxychloroquine.

Other potential treatments are still undergoing clinical trials to test whether they are effective. These include human convalescent plasma, which contains antibodies that are supposed to bind to the virus and prevent it from entering the cell.

There are also medications to modulate the immune response, such as interferon and IL-6 inhibitors, which in some cases may prevent an overly harmful reaction of the immune system. This is commonly referred to as cytokine storm.

A nurse collects convalescent plasma from recovered COVID-19 patients to help the process of treating other COVID-19 patients in Indonesia.
Budiono,/ Sijori/Barcroft Media Images via Getty Images

The new treatment includes one for President Trump.

There is currently no approved treatment for outpatients with asymptomatic or mild to moderate COVID-19 infection. But this seems to be changing. With the release of Eli Lilly and Regeneron’s clinical trial data on the use of laboratory-produced antibodies against the novel coronavirus spike glycoprotein.

In this approach, as with convalescent plasma, antibodies work by binding to the virus and blocking it from entering the cell and multiplying. This may be especially effective at the beginning of the infection, before the illness becomes severe.

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In the first instance of data from an ongoing phase 3 clinical trial, Subjects with COVID-19 who received an injection of a cocktail of monoclonal antibodies against the SARS-CoV-2 glycoprotein had symptoms that persisted for just seven days instead of 13 days. The nose – the upper part of the neck behind the nose – is also reduced.

An update from the president’s doctor on the afternoon of Oct. 2 said that as a precaution, The president was injected with a Regeneron antibody cocktail. This treatment was not widely available. and can only be given under what is known as compassionate use.

on the same day The president reportedly received supplemental oxygen and the first dose of the antiretroviral drug remdesivir. Research has shown that this antiretroviral drug can shorten the length of hospitalization of COVID-19 patients, but only when given before ventilator-required patients.

On Saturday, Oct. 3, the president received a second dose of remdesivir and the first dose of dexamethasone steroids. Dexamethasone is an anti-inflammatory drug in the same class as prednisone. Reduce mortality in COVID-19 patients whose symptoms are severe enough to require supplemental oxygen. But it may make the disease worse in people who are not severely ill.

All of which suggests that the president is getting the modern treatment.

This article was updated on October 5 with new details on President Trump’s treatment for COVID-19.

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